WCRF International Grant panel member

Professor Chris Paraskeva
School of Cellular & Molecular Medicine
Medical Sciences Building
University of Bristol
http://www.bristol.ac.uk/cellmolmed

Professor Chris Paraskeva is Professor of Experimental Oncology and Director of the Cancer Research UK Colorectal Tumour Biology Research Group at the University of Bristol (UK). His academic career has focused on research and educational activities in cellular and molecular biology of colorectal cancer. Before going to Bristol he studied at Manchester and then Oxford University where he obtained his D.Phil. and then held post doctoral fellowships in Cancer Studies at Birmingham University and then Imperial Cancer Research Fund, London before going to Bristol.

He has a long standing interest in cancer prevention and in particular the mechanisms by which non-steroidal anti-inflammatory drugs such as aspirin, and dietary factors such as fiber, exert their chemopreventive properties and their potential exploitation for novel preventive and therapeutic strategies. His current research programme investigates the role of the Prostaglandin E2/COX-2 signaling pathways in colorectal tumorigenesis and chemoprevention, identification of novel biomarkers for the early detection of bowel cancer, and cancer stem cells. His recent work also focuses on understanding the mechanisms by which cancer cells adapt to key tumour microenvironmental stresses such as hypoxia and energy deprivation, to target the tumour microenvironment as a novel chemopreventive and therapeutic approach for bowel cancer.