The team at the University of Bristol is carrying out work to develop and test new methodology for conducting systematic reviews of mechanistic studies in relation to diet, nutrition, physical activity and the development and progression of different cancers. There is currently no existing method for systematically reviewing mechanistic studies similar to that followed for epidemiological studies for the Continuous Update Project (CUP).
In September 2012, the team was awarded a CUP Request for Applications grant in collaboration with World Cancer Research Fund International with the support of the CUP Panel.
This work originally started back in early 2012, when a Mechanisms Protocol Development Group (MPDG) was set up to provide initial advice to WCRF/AICR on developing appropriate methodology for reviewing evidence on mechanisms that supports the epidemiological evidence on cancer prevention and survivorship.
The team at the University of Bristol is led by Dr Sarah Lewis (Principal Investigator) and Professor Richard Martin (Co Principal Investigator).
Others involved in the work are listed below:
University of Bristol:
Dr Mona Jeffreys – Cancer Epidemiology/systematic reviews
Dr Mike Gardner – Animal biology/systematic reviews
Prof Jeff Holly – Molecular biology – IGF and cancer
Dr Tom Gaunt – Genetic epidemiology/bioinformatics
Prof Jonathan Sterne – Meta-analysis and systematic review methodology
Professor Julian Higgins – Meta-analysis and systematic review methodology
Prof George Davey Smith – Epidemiology
Prof Christos Paraskeva – Molecular biology
Prof Steve Thomas – Epidemiology of head and neck cancer
Dr Pauline Emmett – Nutritional epidemiology
Dr Kate Northstone – Nutritional Epidemiology
Cath Borwick – Librarian/ Search strategies
University of Cambridge:
Dr Suzanne Turner – Animal models
Dr Sabina Rinaldi – Hormones and cancer
And Professor Martin Wiseman, Dr Panagiota Mitrou and Dr Rachel Thompson on behalf of WCRF International. Dr Pierre Hainut (Director, Institut Albert Bonniot/GIRC, Grenoble France) is also an advisor to WCRF International.