Ovarian cancer

The updated systematic literature review (SLR) and report were published in March 2014.

The research team at Imperial College London produced the updated systematic literature review of the evidence on food, nutrition, physical activity, and body fatness relating to the prevention of ovarian cancer in 2013. There were 128 ovarian cancer articles included in the CUP review, including 80 new articles identified in the CUP updated search.

The Expert Panel agreed that the updated CUP findings confirmed the evidence that adult attained height is a convincing cause of ovarian cancer, although height is unlikely to directly modify the risk of cancer it is a marker for genetic, environmental, hormonal and nutritional factors affecting growth during the period from preconception to completion of linear growth. The Panel also made a new judgement that body fatness (marked by body mass index) is probably a cause of ovarian cancer.

The Ovarian Cancer 2014 Report updates the ovarian cancer section of the Second Expert Report (section 7.11) and is based on the findings of the 2013 SLR and the CUP Expert Panel discussion in June 2013.

Conclusions from the updated evidence for ovarian cancer

The Panel's judgements are shown below. Further details of the analyses can be found in the Ovarian Cancer 2014 Report. Information on how the Panel judged the evidence can be found in Appendix 1 of the report, and further details in chapter 3 of the Second Expert Report.

Food, nutrition, physical activity and ovarian cancer 2014

Published findings in peer-reviewed journals

Selected findings from the ovarian cancer CUP update have been published in a peer-reviewed journal.  The details of the paper and link to the abstract in PubMed are below:

Anthropometric factors and ovarian cancer risk: A systematic review and non-linear dose-response meta-analysis of prospective studies. Aune D, Navarro Rosenblatt DA, Chan DS, Abar L, Vingeliene S, Vieira AR, Greenwood DC, & Norat T. Int J Cancer 2015; 136(8): 1888-98. Abstract.