The aim of the project is to study the role of diet and body weight in the development of multiple myeloma from its precursors. We do this to identify actionable insights for lifestyle modifications that could empower individuals and give them agency to shape their own health journey and improve their quality of life long term.– Dr Sæmundur Rögnvaldsson
Background
Multiple myeloma (MM) is a serious cancer of the immune system that develops over decades from preexisting, non-cancerous conditions in which cells in the bone marrow grow abnormally (monoclonal gammopathy of undetermined significance – MGUS and smoldering multiple myeloma – SMM). Some evidence suggests that diet and obesity are linked to MM, but this is based on small studies with significant design flaws.
Aims and objectives
The goal of iStopMM is to evaluate population-based screening for abnormal cell growth in the bone marrow, with the aim of preventing MM and improving outcomes for MM and related diseases. We aim to identify modifiable factors, such as diet and body weight, to empower individuals with these preexisting conditions to take an active role in managing their health and reducing their risk of developing MM.
How it will be done
The project builds on the Iceland Screens, Treats, or Prevents Multiple Myeloma study (iStopMM), a nationwide population-based screening study and randomised trial of follow-up strategies. In this study, 75,422 Icelanders aged 40 and older (51% of the total population) have been screened. Individuals with preexisting conditions enter a follow-up phase that involves regular monitoring of their weight, and all participants complete questionnaires regarding their weight and dietary habits.
Potential impact
By analysing the extensive data collected in this unique setting, we aim to gain high-quality insights into the role of diet and obesity in the development and progression of MM.